Article

Binding dynamics shape germinal center broadly neutralizing responses to HIV priming

2026-06-01

Abstract excerpt

<title>Abstract</title> <p>Inducing broadly neutralizing antibodies (bnAbs) is central to HIV vaccine efforts, but bnAb precursors are rare, often inactive, and require extensive somatic hypermutation (SHM) to recognize diverse, glycan-shielded epitopes. Germline-targeting immunogens (GTs) aim to jump-start this process, but determinants of success remain unclear. Here we establish a bnAb precursor-trackable mode...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9a9f0197-6b34-52f8-81d1-42079fd9723f
DOI: 10.21203/rs.3.rs-9368628/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Binding dynamics shape germinal center broadly neutralizing responses to HIV primingDOI 10.21203/rs.3.rs-9368628/v1Read

Binding dynamics shape germinal center broadly neutralizing responses to HIV primingSemantic proximity Read

HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen.Semantic proximity Read

Diverse priming outcomes under conditions of very rare precursor B cellsSemantic proximity Read

Long-lasting germinal center responses to a priming immunization with continuous proliferation and somatic mutationSemantic proximity Read

Vaccine genetics of IGHV1-2 VRC01-class broadly neutralizing antibody precursor naïve human B cellsSemantic proximity Read

Human immunoglobulin repertoire analysis guides design of vaccine priming immunogens targeting HIV V2-apex broadly neutralizing antibody precursorsSemantic proximity Read

Computing the inducibility of B cell lineages under a context-dependent model of affinity maturation: Applications to sequential vaccine designSemantic proximity Read

An engineered immunogen activates diverse HIV broadly neutralizing antibody precursors and promotes acquisition of improbable mutations.Semantic proximity Read

Rational HIV Immunogen Design to Target Specific Germline B Cell ReceptorsSemantic proximity Read

Germline-Targeting Strategies to Induce bNAbs against HIV-1Semantic proximity Read

Differences in Allelic Frequency and CDRH3 Region Limit the Engagement of HIV Env Immunogens by Putative VRC01 Neutralizing Antibody Precursors.Semantic proximity Read

Vaccination induces HIV broadly neutralizing antibody precursors in humans.Semantic proximity Read