Article

Binding dynamics shape germinal center broadly neutralizing responses to HIV priming

2026-05-15

Abstract excerpt

<h4>SUMMARY</h4> Inducing broadly neutralizing antibodies (bnAbs) is central to HIV vaccine efforts, but bnAb precursors are rare, often inactive, and require extensive somatic hypermutation (SHM) to recognize diverse, glycan-shielded epitopes. Germline-targeting immunogens (GTs) aim to jump-start this process, but determinants of success remain unclear. Here we establish a bnAb precursor-trackable model that rev...

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Literature Corpus work: 29ef4895-349a-5596-8be6-38ad8dc6b23b
DOI: 10.64898/2026.05.12.724749

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