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Article

Optimal Sequential Immunization Can Focus Antibody Responses against Diversity Loss and Distraction.

PLoS computational biology - 1 Jan 2017

Wang Shenshen

Abstract excerpt

Affinity maturation is a Darwinian process in which B lymphocytes evolve potent antibodies to encountered antigens and generate immune memory. Highly mutable complex pathogens present an immense antigenic diversity that continues to challenge natural immunity and vaccine design. Induction of broadly neutralizing antibodies (bnAbs) against this diversity by vaccination likely requires multiple exposures to...

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Identifiers

PMID: 28135270
DOI: 10.1371/journal.pcbi.1005336
PMCID: PMC5279722

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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