Article

Anti-HIV-1 B cell responses are dependent on B cell precursor frequency and antigen binding affinity

2018-03-02

Abstract excerpt

The discovery that humans can produce potent broadly neutralizing antibodies (bNAbs) to several different epitopes on the HIV-1 spike has reinvigorated efforts to develop an antibody based HIV-1 vaccine. Antibody cloning from single cells revealed that nearly all bNAbs show unusual features that could help explain why it has not been possible to elicit them by traditional vaccination, and instead that it would req...

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Literature Corpus work: 8a9ba4e2-83ae-5d5a-9f5d-67c6fb9a4af3
DOI: 10.1101/275438

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