Article

Multiscale affinity maturation simulations to elicit broadly neutralizing antibodies against HIV

2021-09-02

Abstract excerpt

The design of vaccines against highly mutable pathogens, such as HIV and influenza, requires a detailed understanding of how the adaptive immune system responds to encountering multiple variant antigens (Ags). Here, we describe a multiscale model of B cell receptor (BCR) affinity maturation that employs actual BCR nucleotide sequences and treats BCR/Ag interactions in atomistic detail. We apply the model to simula...

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Literature Corpus work: 39a24a04-c3a8-52a8-adea-4722a99702d1
DOI: 10.1101/2021.09.01.458482

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