Article

Mapping immune imprinting zones enables predictive vaccination optimization

2025-10-09

Abstract excerpt

<title>Abstract</title> <p>Immune imprinting, where prior exposures shape antibody responses to variant antigens, remains a central obstacle to optimizing vaccination against evolving viruses. Here, we present DynaVac, a mechanistic framework that models antigen-specific B cell dynamics, particularly the competition between memory and naive compartments across antigenic distances. Calibrated on neutralization tit...

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Literature Corpus work: f4f376e2-3dce-5dca-821c-6acba908972b
DOI: 10.21203/rs.3.rs-7719056/v1

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