Article

Rapid selection of HIV envelopes that bind to neutralizing antibody B cell lineage members with functional improbable mutations

2021-01-04

Abstract excerpt

<h4>Summary</h4> Elicitation of broadly neutralizing antibodies (bnAbs) by an HIV vaccine will involve priming the immune system to activate antibody precursors, followed by boosting immunizations to select for antibodies with functional features required for neutralization breadth. The higher the number of acquired mutations necessary for function, the more convoluted are the antibody developmental pathways. HIV...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 040c0106-43d7-549c-a53e-446655b7a43a
DOI: 10.1101/2021.01.04.425252

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Rapid selection of HIV envelopes that bind to neutralizing antibody B cell lineage members with functional improbable mutationsDOI 10.1101/2021.01.04.425252Read

Rapid selection of HIV envelopes that bind to neutralizing antibody B cell lineage members with functional improbable mutations.Semantic proximity Read

An engineered immunogen activates diverse HIV broadly neutralizing antibody precursors and promotes acquisition of improbable mutations.Semantic proximity Read

Functional Improbable Antibody Mutations Critical for HIV Broadly Neutralizing Antibody DevelopmentSemantic proximity Read

Mutation-guided vaccine design: A process for developing boosting immunogens for HIV broadly neutralizing antibody induction.Semantic proximity Read

<scp>HIV</scp>‐1 neutralizing antibodies: understanding nature's pathwaysSemantic proximity Read

VRC34-Antibody Lineage Development Reveals How a Required Rare Mutation Shapes the Maturation of a Broad HIV-Neutralizing Lineage.Semantic proximity Read

De novo identification of VRC01 class HIV-1-neutralizing antibodies by next-generation sequencing of B-cell transcripts.Semantic proximity Read

HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen.Semantic proximity Read

Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodiesSemantic proximity Read

Differences in Allelic Frequency and CDRH3 Region Limit the Engagement of HIV Env Immunogens by Putative VRC01 Neutralizing Antibody Precursors.Semantic proximity Read

Functional Relevance of Improbable Antibody Mutations for HIV Broadly Neutralizing Antibody Development.Semantic proximity Read

Vaccination induces maturation in a mouse model of diverse unmutated VRC01-class precursors to HIV-neutralizing antibodies with >50% breadth.Semantic proximity Read