OLGA: fast computation of generation probabilities of B- and T-cell receptor amino acid sequences and motifs

Abstract excerpt

<h4>Motivation</h4> High-throughput sequencing of large immune repertoires has enabled the development of methods to predict the probability of generation by V(D)J recombination of T- and B-cell receptors of any specific nucleotide sequence. These generation probabilities are very non-homogeneous, ranging over 20 orders of magnitude in real repertoires. Since the function of a receptor really depends on its prote...

Topics

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• Antibodies
• Antibody Affinity
• Broadly Neutralizing Antibodies
• Monoclonal and Polyclonal Antibodies Research
• Mutation
• Probability
• T-cell and B-cell Immunology
• vaccines and immunoinformatics approaches

Identifiers and source

Literature Corpus work

62a6b23d-2067-5ccd-b1f0-f68720db5850

DOI

10.1101/367904