Article

Humanized APOE mouse brain volume increases over age irrespective of sex and APOE genotype: Implications for translational validity to the human

2025-10-28

Abstract excerpt

Translational validity of mouse models of human aging and late-onset Alzheimer’s disease (LOAD) risk are essential for both fundamental mechanistic science and therapeutic development. Given that the strongest risk factors for LOAD are age, female sex, and APOE-ε4 carriership, models must reflect these biological variables and disease phenotypes. The use of mouse models with humanized APOE (hAPOE) is a key strateg...

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Literature Corpus work: bdfa8aeb-a0bf-5295-8f36-e14fce77c716
DOI: 10.1101/2025.10.27.684892

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