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Addition of humanized APP to humanized <i>APOE</i> mouse model reduces brain size and increases the ratio of cortical representation

2026-05-05

Abstract excerpt

<h4>ABSTRACT</h4> <h4>INTRODUCTION</h4> Age, Apolipoprotein E4 ( APOE 4) genotype, and biological sex are major risk factors for late-onset Alzheimer’s disease (LOAD). Neuroimaging is central to its characterization, and preclinical mouse models enable controlled investigation of these factors. To date, humanized APOE 4 has not recapitulated LOAD-relevant brain phenotypes. Given the central role of amyloid pre...

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Literature Corpus work
335a0be2-03b0-5f03-8109-abe08956c01a
DOI
10.64898/2026.05.04.722764
Open publication

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Addition of humanized APP to humanized <i>APOE</i> mouse model reduces brain size and increases the ratio of cortical representationDOI 10.64898/2026.05.04.722764
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