Article
Molecular characterization of humanized APOE mouse models reveals source and genotype dependent differences.
Molecular neurodegeneration - 24 Mar 2026
Wang Na, Yu Gefei, Wang Zhen, Alnobani Alla, Jeevaratnam Suren, Zhang Xue, McReynolds Meghan, Chang Yuzhou, Qi Fangfang, Tauer William, Rosenberg Cassandra, Wren Melissa, Ikezu Tadafumi C, Martens Yuka A, Wang Minghui, Zhang Bin, Carter Gregory W, Sasner Michael, Holtzman David M, Peng Junmin, Wu Long-Jun, Kanekiyo Takahisa, Liu Chia-Chen, Bu Guojun
Abstract excerpt
BACKGROUND: Humanized APOE targeted-replacement (TR) mice are essential tools for studying apoE isoform effects in Alzheimer’s disease (AD) and other apoE-related disorders. Despite their widespread use, existing APOE mouse models, generated with different gene targeting strategies, have not been directly compared in terms of apoE isoform expression, lipid profiles, and transcriptomic signatures. Such differences...
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