Alzheimer's disease pathology in APOE transgenic mouse models: The Who, What, When, Where, Why, and How.

doi:10.1016/j.nbd.2020.104811

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Article

Alzheimer's disease pathology in APOE transgenic mouse models: The Who, What, When, Where, Why, and How.

Neurobiology of disease - 1 Jun 2020

Lewandowski Cutler T, Maldonado Weng Juan, LaDu Mary Jo

Abstract excerpt

The focus on amyloid plaques and neurofibrillary tangles has yielded no Alzheimer's disease (AD) modifying treatments in the past several decades, despite successful studies in preclinical mouse models. This inconsistency has caused a renewed focus on improving the fidelity and reliability of AD mouse models, with disparate views on how this improvement can be accomplished. However, the interactive effects of the...

Topics

Alleles
Alzheimer Disease
Amyloid beta-Peptides
Animals
Apolipoprotein E4
Apolipoproteins E
Cognitive Dysfunction
Disease Models, Animal
Female
Genotype
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Mice

Mice, Transgenic

Plaque, Amyloid

Reproducibility of Results

tau Proteins

Source

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Identifiers

PMID: 32087290
DOI: 10.1016/j.nbd.2020.104811
PMCID: PMC7150653

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