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Article

Contributions of sex and genotype to exploratory behavior differences in an aged humanized APOE mouse model of late-onset Alzheimer's disease.

Learning & memory (Cold Spring Harbor, N.Y.) - 1 Sept 2022

McLean John W, Bhattrai Avnish, Vitali Francesca, Raikes Adam C, Wiegand Jean-Paul L, Brinton Roberta Diaz

Abstract excerpt

Age, genetics, and chromosomal sex have been identified as critical risk factors for late-onset Alzheimer's disease (LOAD). The predominant genetic risk factor for LOAD is the apolipoprotein E ε4 allele (APOE4), and the prevalence of LOAD is higher in females. However, the translational validity of APOE4 mouse models for AD-related cognitive impairment remains to be fully determined. The present study...

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Identifiers

PMID: 36206387
DOI: 10.1101/lm.053588.122
PMCID: PMC9488030

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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