Article

A multi-discipline phenotyping platform for late-onset Alzheimer’s disease employed on a novel, humanized APOEε4.Trem2*R47H mouse model

2021-01-07

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Late-onset Alzheimer’s Disease (AD) (LOAD) is the most common neurodegenerative disease. Despite extensive efforts to understand disease progression there are currently no approved disease modifying interventions to delay or reverse neurodegeneration caused by AD. Repeated failures in human trials, despite promising preclinical results in amyloidogenic mouse mod...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f0d20290-5216-596f-8e4b-0173810c41f7
DOI: 10.21203/rs.3.rs-135213/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A multi-discipline phenotyping platform for late-onset Alzheimer’s disease employed on a novel, humanized APOEε4.Trem2*R47H mouse modelDOI 10.21203/rs.3.rs-135213/v1Read

APOEe4.Trem2*R47H Mice Show Changes in Alzheimer’s Disease-Relevant Processes in the Absence of Amyloid PlaquesSemantic proximity Read

Characterizing Molecular and Synaptic Signatures in mouse models of Late-Onset Alzheimer’s Disease Independent of Amyloid and Tau PathologySemantic proximity Read

<i>In vivo</i> validation of late-onset Alzheimer’s disease genetic risk factorsSemantic proximity Read

In vivo validation of late-onset Alzheimer's disease genetic risk factors.Semantic proximity Read

Systematic Phenotyping and Characterization of the 5xFAD mouse model of Alzheimer’s DiseaseSemantic proximity Read

Systematic phenotyping and characterization of the 5xFAD mouse model of Alzheimer's disease.Semantic proximity Read

Genetic perturbations of disease risk genes in mice capture transcriptomic signatures of late-onset Alzheimer’s diseaseSemantic proximity Read

Systematic phenotyping and characterization of the 3xTg-AD mouse model of Alzheimer’s DiseaseSemantic proximity Read

A novel systems biology approach to evaluate mouse models of late-onset Alzheimer’s diseaseSemantic proximity Read

Alzheimer's Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways.Semantic proximity Read

A novel systems biology approach to evaluate mouse models of late-onset Alzheimer’s diseaseSemantic proximity Read