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Article

APOE in the normal brain

5 Jan 2020

Abstract excerpt

The APOE4 protein affects the primary neuropathological markers of Alzheimer's disease (AD): amyloid plaques, neurofibrillary tangles, and gliosis. These interactions have been investigated to understand the strong effect of APOE genotype on risk of AD. However, APOE genotype has strong effects on processes in normal brains, in the absence of the hallmarks of AD. We propose that CNS APOE is involved in processes...

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Identifiers

PMID: 31911114
DOI: 10.1016/j.nbd.2019.104724

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