Article

<i>APOE4</i> genotype and old age interact to impact cerebrovascular function, brain volume, and neuroinflammation in mice

2026-07-11

Abstract excerpt

<h4>ABSTRACT</h4> Old age and the apolipoprotein E ε4 ( APOE4) genotype are two of the greatest risk factors for late-onset Alzheimer’s disease (LOAD). However, the interaction between these is poorly understood, as most preclinical studies use young mice. Therefore, we assessed the interaction between APOE genotype and age across a comprehensive set of cerebrovascular and related outcomes. We performed in viv...

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Literature Corpus work: 2151d408-6add-5f1f-b013-dc5f2b44a9fa
DOI: 10.64898/2026.07.07.736860

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