Article

APOEe4.Trem2*R47H Mice Show Changes in Alzheimer’s Disease-Relevant Processes in the Absence of Amyloid Plaques

2021-06-15

Abstract excerpt

<title>Abstract</title> <p>Late-onset Alzheimer’s disease (LOAD) is the most common human neurodegenerative disease. Legacy amyloidogenic mouse models have been useful for understanding disease progression, however in the face of failing human trials more focus on disease translation with new mouse strains that better model human Alzheimer’s disease (AD) is required. MODEL-AD (Model Organism Development and Evalu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d306b471-ac63-5fa4-acc4-71618d2b80e7
DOI: 10.21203/rs.3.rs-580913/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

APOEe4.Trem2*R47H Mice Show Changes in Alzheimer’s Disease-Relevant Processes in the Absence of Amyloid PlaquesDOI 10.21203/rs.3.rs-580913/v1Read

A multi-discipline phenotyping platform for late-onset Alzheimer’s disease employed on a novel, humanized APOEε4.Trem2*R47H mouse modelSemantic proximity Read

<i>In vivo</i> validation of late-onset Alzheimer’s disease genetic risk factorsSemantic proximity Read

In vivo validation of late-onset Alzheimer's disease genetic risk factors.Semantic proximity Read

Systematic Phenotyping and Characterization of the 5xFAD mouse model of Alzheimer’s DiseaseSemantic proximity Read

Characterizing Molecular and Synaptic Signatures in mouse models of Late-Onset Alzheimer’s Disease Independent of Amyloid and Tau PathologySemantic proximity Read

Systematic phenotyping and characterization of the 5xFAD mouse model of Alzheimer's disease.Semantic proximity Read

Genetic perturbations of disease risk genes in mice capture transcriptomic signatures of late-onset Alzheimer’s diseaseSemantic proximity Read

Genetic perturbations of disease risk genes in mice capture transcriptomic signatures of late-onset Alzheimer’s diseaseSemantic proximity Read

Differential splicing of neuronal genes in a Trem2*R47H mouse model mimics alterations associated with Alzheimer's disease.Semantic proximity Read

Alzheimer's Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways.Semantic proximity Read

A novel systems biology approach to evaluate mouse models of late-onset Alzheimer’s diseaseSemantic proximity Read

Trem2 <sup>R47H</sup> and reduced <i>TREM2</i> expression both mimic human Alzheimer’s disease signatures in miceSemantic proximity Read