Article
Evidence in support of chromosomal sex influencing plasma based metabolome vs APOE genotype influencing brain metabolome profile in humanized APOE male and female mice.
PloS one - 1 Jan 2020
Shang Yuan, Mishra Aarti, Wang Tian, Wang Yiwei, Desai Maunil, Chen Shuhua, Mao Zisu, Do Loi, Bernstein Adam S, Trouard Theodore P, Brinton Roberta D
Abstract excerpt
Late onset Alzheimer's disease (LOAD) is a progressive neurodegenerative disease with four well-established risk factors: age, APOE4 genotype, female chromosomal sex, and maternal history of AD. Each risk factor impacts multiple systems, making LOAD a complex systems biology challenge. To investigate interactions between LOAD risk factors, we performed multiple scale analyses, including metabolomics,...
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