Article

Protein binding and methylation on looping chromatin accurately predict distal regulatory interactions

2015-07-09

Abstract excerpt

Identifying the gene targets of distal regulatory sequences is a challenging problem with the potential to illuminate the causal underpinnings of complex diseases. However, current experimental methods to map enhancer-promoter interactions genome-wide are limited by their cost and complexity. We present TargetFinder , a computational method that reconstructs a cell’s three-dimensional regulatory landscape from tw...

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Literature Corpus work: bc844076-d5ce-5359-abed-71e6c7822093
DOI: 10.1101/022293

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