Article

Minimum entropy framework identifies a novel class of genomic functional elements and reveals regulatory mechanisms at human disease loci

2023-06-12

Abstract excerpt

We introduce CoRE-BED, a framework trained using 19 epigenomic features in 33 major cell and tissue types to predict cell-type-specific regulatory function. CoRE-BED identifies nine functional classes de-novo , capturing both known and new regulatory categories. Notably, we describe a previously undercharacterized class that we term Development Associated Elements (DAEs), which are highly enriched in cell types w...

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Identifiers and source

Literature Corpus work: 7862ca91-b2a0-5450-b6df-9771bd366bb8
DOI: 10.1101/2023.06.11.544507

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