Article

Promoter-Enhancer Interactions Identified from Hi-C Data using Probabilistic Models and Hierarchical Topological Domains

2017-01-18

Abstract excerpt

Proximity-ligation methods as Hi-C allow us to map physical DNA-DNA interactions along the genome, and reveal its organization in topologically associating domains (TADs). As Hi-C data accumulate, computational methods were developed for identifying domain borders in multiple cell types and organisms. Here, we present PSYCHIC, a computational approach for analyzing Hi-C data and identifying Promoter-Enhancer inter...

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Literature Corpus work: c40c2742-8d9b-5518-9a17-c4b627058ff6
DOI: 10.1101/101220

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