Article
Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters.
Cell - 17 Nov 2016
Javierre Biola M, Burren Oliver S, Wilder Steven P, Kreuzhuber Roman, Hill Steven M, Sewitz Sven, Cairns Jonathan, Wingett Steven W, Várnai Csilla, Thiecke Michiel J, Burden Frances, Farrow Samantha, Cutler Antony J, Rehnström Karola, Downes Kate, Grassi Luigi, Kostadima Myrto, Freire-Pritchett Paula, Wang Fan, Stunnenberg Hendrik G, Todd John A, Zerbino Daniel R, Stegle Oliver, Ouwehand Willem H, Frontini Mattia, Wallace Chris, Spivakov Mikhail, Fraser Peter
Abstract excerpt
Long-range interactions between regulatory elements and gene promoters play key roles in transcriptional regulation. The vast majority of interactions are uncharted, constituting a major missing link in understanding genome control. Here, we use promoter capture Hi-C to identify interacting regions of 31,253 promoters in 17 human primary hematopoietic cell types. We show that promoter interactions are highly cell...
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