Article
Germline genetic variation impacts clonal hematopoiesis landscape and progression to malignancy.
Nature genetics - 1 Aug 2025
Liu Jie, Tran Duc, Xue Liying, Wiley Brian J, Vlasschaert Caitlyn, Watson Caroline J, MacGregor Hamish A J, Zong Xiaoyu, Chan Irenaeus C C, Das Indraniel, Uddin Md Mesbah, Niroula Abhishek, Griffin Gabriel, Ebert Benjamin L, Mack Taralynn, Pershad Yash, Sharber Brian, Berger Michael, Zehir Ahmet, Ptashkin Ryan, Levine Ross L, Papaemmanuil Elli, Joseph Vijai, Gao Teng, Kemel Yelena, Mandelker Diana, Stopsack Konrad H, Pharoah Paul D P, Mukherjee Semanti, Ding Li, Cao Yin, Walter Matthew J, Blundell Jamie R, Chatterjee Nilanjan, Offit Kenneth, Godley Lucy A, Link Daniel C, Stadler Zsofia K, Bick Alexander G, Natarajan Pradeep, Bolton Kelly L
Abstract excerpt
With age, clonal expansions occur pervasively across normal tissues yet only in rare instances lead to cancer, despite being driven by well-established cancer drivers. Characterization of the factors that influence clonal progression is needed to inform interventional approaches. Germline genetic variation influences cancer risk and shapes tumor mutational profile, but its influence on the mutational landscape of...
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