Article

Clonal dynamics of haematopoiesis across the human lifespan

2021-08-16

Abstract excerpt

Age-related change in human haematopoiesis causes reduced regenerative capacity 1 , cytopenias 2 , immune dysfunction 3 and increased risk of blood cancer. The cellular alterations that underpin the abruptness of this functional decline after the age of 70 years remain elusive. We sequenced 3579 genomes from single-cell-derived colonies of haematopoietic stem cell/multipotent progenitors (HSC/MPPs) across 10 ha...

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Literature Corpus work: 0228766e-c941-52cd-a0d5-0dc6bf709d58
DOI: 10.1101/2021.08.16.456475

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