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Article

Clonal Hematopoiesis: Origins and determinants of evolution.

Leukemia research - 1 Jun 2023

Mendez Lourdes M, Patnaik Mrinal M

Abstract excerpt

The accrual of somatic mutations is a byproduct of aging. When a clone bearing a somatic genetic alteration, conferring comparative competitive advantage, displays sufficient outgrowth to become detectable amongst an otherwise polyclonal background in the hematopoietic system, this is called clonal hematopoiesis (CH). Somatic genetic alterations observed in CH include point mutations in cancer related genes,...

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PMID: 37075557
DOI: 10.1016/j.leukres.2023.107076

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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