Clonal Hematopoiesis: Origins and determinants of evolution.

doi:10.1016/j.leukres.2023.107076

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Article

Clonal Hematopoiesis: Origins and determinants of evolution.

Leukemia research - 1 Jun 2023

Mendez Lourdes M, Patnaik Mrinal M

Abstract excerpt

The accrual of somatic mutations is a byproduct of aging. When a clone bearing a somatic genetic alteration, conferring comparative competitive advantage, displays sufficient outgrowth to become detectable amongst an otherwise polyclonal background in the hematopoietic system, this is called clonal hematopoiesis (CH). Somatic genetic alterations observed in CH include point mutations in cancer related genes,...

Topics

Humans
Clonal Hematopoiesis
Hematopoiesis
Hematologic Neoplasms
Pancytopenia
Myeloproliferative Disorders
Clonal Evolution
Mutation

Source

Open in PubMed

Identifiers

PMID: 37075557
DOI: 10.1016/j.leukres.2023.107076

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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