Article

KDM6A facilitates Xist upregulation at the onset of X inactivation

2024-06-27

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> X chromosome inactivation (XCI) is a female-specific process in which one X chromosome is silenced to balance X-linked gene expression between the sexes. XCI is initiated in early development by upregulation of the lncRNA Xist on the future inactive X (Xi). A subset of X-linked genes escape silencing and thus have higher expression in females, suggesting female-...

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Literature Corpus work: 7e27f773-fe66-54e6-ade8-f36e98e74794
DOI: 10.21203/rs.3.rs-4559334/v1

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