Article

Derivation of a minimal functional XIST by combining human and mouse interaction domains

2022-09-02

Abstract excerpt

XIST is a 17-19 kb long non-coding RNA critical for X-chromosome inactivation. Tandem repeats within the RNA serve as functional domains involved in the cis-limited recruitment of heterochromatic changes and silencing. To explore the sufficiency of these domains while generating a functional miniXIST for targeted silencing approaches, we tested inducible constructs integrated into 8p in a male cell line. Previous...

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Literature Corpus work: 34ef1fef-d3d3-5e48-9bd0-f46ba4069d95
DOI: 10.1101/2022.09.02.506429

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