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Neuronal NOX4 knockdown alleviates pathological tau-related alterations in a humanized mouse model of tauopathy

2020-10-14

Abstract excerpt

Approximately 44 million people worldwide live with Alzheimer’s disease (AD) or a related form of dementia. Aggregates of the microtubule-associated protein tau are a common marker of these neurodegenerative diseases collectively termed as tauopathies. However, all therapeutic attempts based on tau have failed, suggesting that tau may only indicate a higher-level causal mechanism. For example, increasing levels of...

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Literature Corpus work
b9451065-1e7f-5b9f-8f7e-a55de465ba29
DOI
10.1101/2020.10.14.338954
Open publication

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Neuronal NOX4 knockdown alleviates pathological tau-related alterations in a humanized mouse model of tauopathyDOI 10.1101/2020.10.14.338954
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