Back to search

Article

<i>Ndufs4</i> knockout induces transcriptomic signatures of Alzheimer’s Diseases that are partially reversed by mitochondrial complex I inhibitor

2024-02-21

Abstract excerpt

Mitochondrial dysfunction is well documented in Alzheimer’s Disease (AD). However, whether it instigates the onset of AD remains unclear. We demonstrate that a reduction of complex I activity in wild type (WT) mice caused by a global knockout of Ndufs4 , an accessory mitochondrial complex I subunit, was sufficient to induce transcriptomic changes in the brain reminiscent of those observed in AD patients and famil...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
f04e6742-10e7-502f-9cb1-71fcd4d19a20
DOI
10.1101/2024.02.20.581247
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
<i>Ndufs4</i> knockout induces transcriptomic signatures of Alzheimer’s Diseases that are partially reversed by mitochondrial complex I inhibitorDOI 10.1101/2024.02.20.581247
Mitochondrial complex I deficiency induces Alzheimer's disease–like signatures that are reversible by targeted therapySemantic proximity
Transcriptomic and epigenomic landscapes of Alzheimer's disease evidence mitochondrial-related pathwaysSemantic proximity
Single Nucleus Transcriptome Data from Alzheimer’s Disease Mouse Models Yield New Insight into PathophysiologySemantic proximity
<i>TOMM40</i> suppression promotes neuronal cholesterol imbalance and molecular and behavioral phenotypes of Alzheimer’s diseaseSemantic proximity
A mitochondrial-immune axis drives the transcriptomic transition from brain aging to Alzheimer’s diseaseSemantic proximity
Functional Analysis of Late-Onset Alzheimer’s Disease Risk Genes in <i>Caenorhabditis elegans</i> Identifies Regulators of Neuronal AgingSemantic proximity
CEND1 deficiency induces mitochondrial dysfunction and cognitive impairment in Alzheimer’s diseaseSemantic proximity
Age- and sex-associated alterations in hypothalamic mitochondrial bioenergetics and inflammatory-associated signaling in the 3xTg mouse model of Alzheimer’s diseaseSemantic proximity
RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s DiseaseSemantic proximity
Proteomic and metabolomic analyses of mitochondrial complex I-deficient mouse model generated by spontaneous B2 short interspersed nuclear element (SINE) insertion into NADH dehydrogenase (ubiquinone) Fe-S protein 4 (Ndufs4) gene.Semantic proximity
Apoe4 and Alzheimer’s Disease Pathogenesis—Mitochondrial Deregulation and Targeted Therapeutic StrategiesSemantic proximity
miRNA mediated mitochondrial function and gene regulation associated with Alzheimer’s diseaseSemantic proximity
Select a neighboring publication to make it the new centre.