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NOX4-mediated astrocyte ferroptosis in Alzheimer’s disease

2 Jul 2024

Abstract excerpt

This study investigates NADPH oxidase 4 (NOX4) involvement in iron-mediated astrocyte cell death in Alzheimer's Disease (AD) using single-cell sequencing data and transcriptomes. We analyzed AD single-cell RNA sequencing data, identified astrocyte marker genes, and explored biological processes in astrocytes. We integrated AD-related chip data with ferroptosis-related genes, highlighting NOX4. We validated NOX4's...

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PMID: 38956702
DOI: 10.1186/s13578-024-01266-w

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