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Neuron-derived Thioredoxin-80: a novel regulator of type-I interferon response in microglia

2022-03-11

Abstract excerpt

Oxidative stress and neuroinflammation play a central role in Alzheimer’s Disease (AD) pathogenesis. However, the mechanism by which these processes lead to neurodegeneration is still not fully understood. Thioredoxin-1 (Trx1) is an antioxidant protein that can be cleaved into a peptide known as Thioredoxin-80 (Trx80), which modulates monocyte function in the periphery and shows anti-amyloidogenic properties in th...

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Literature Corpus work
f566bc1b-dc6b-5e53-ab86-4b9aeb2f8143
DOI
10.1101/2022.03.09.483648
Open publication

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Neuron-derived Thioredoxin-80: a novel regulator of type-I interferon response in microgliaDOI 10.1101/2022.03.09.483648
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