Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Role of the NADPH Oxidase NOX2 in Prion Pathogenesis

11 Dec 2014

Abstract excerpt

Prion infections cause neurodegeneration, which often goes along with oxidative stress. However, the cellular source of reactive oxygen species (ROS) and their pathogenetic significance are unclear. Here we analyzed the contribution of NOX2, a prominent NADPH oxidase, to prion diseases. We found that NOX2 is markedly upregulated in microglia within affected brain regions of patients with Creutzfeldt-Jakob disease...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcoholism and Thiamine Deficiency
Share to Neuroinflammation and Neurodegeneration Mechanisms
Share to Prion Diseases and Protein Misfolding

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25502554
DOI: 10.1371/journal.ppat.1004531

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Role of the NADPH Oxidase NOX2 in Prion PathogenesisPMID 25502554Read ↗

Neuronal NADPH oxidase 2 in Parkinson’s disease pathogenesisSemantic proximity Read ↗

Neuronal NOX4 knockdown alleviates pathological tau-related alterations in a humanized mouse model of tauopathySemantic proximity Read ↗

NADPH oxidase and extracellular regulated kinases 1/2 are targets of prion protein signaling in neuronal and nonneuronal cells.Semantic proximity Read ↗

NG2 glia protect against prion neurotoxicity by inhibiting prostaglandin E2 signalingSemantic proximity Read ↗

Implication of type 4 NADPH oxidase (NOX4) in tauopathySemantic proximity Read ↗

NOX2 Inhibition Enables Retention of the Circadian Clock in BV2 Microglia and Primary MacrophagesSemantic proximity Read ↗

Molecular Roles of NADPH Oxidase-Mediated Oxidative Stress in Alzheimer’s Disease: Isoform-Specific ContributionsSemantic proximity Read ↗

Triggering receptor expressed on myeloid cells-2 is involved in prion-induced microglial activation but does not contribute to prion pathogenesis in mouse brains.Semantic proximity Read ↗

NOX2 deficiency alters macrophage phenotype through an IL-10/STAT3 dependent mechanism: implications for traumatic brain injury.Semantic proximity Read ↗

Lack of prion protein expression results in a neuronal phenotype sensitive to stress.Semantic proximity Read ↗

Gp91phox (NOX2) in classically activated microglia exacerbates traumatic brain injury.Semantic proximity Read ↗

Molecular evolution of the reactive oxygen-generating NADPH oxidase (Nox/Duox) family of enzymesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.