Article

Mitochondrial complex III-derived ROS amplify immunometabolic changes in astrocytes and promote dementia pathology

2024-08-20

Abstract excerpt

Neurodegenerative disorders alter mitochondrial functions, including the production of reactive oxygen species (ROS). Mitochondrial complex III (CIII) generates ROS implicated in redox signaling, but its triggers, targets, and disease relevance are not clear. Using site-selective suppressors and genetic manipulations together with mitochondrial ROS imaging and multiomic profiling, we found that CIII is the dominan...

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Literature Corpus work: c084cda4-b2c8-5704-b6c0-df11cdd8fb08
DOI: 10.1101/2024.08.19.608708

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