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Implication of type 4 NADPH oxidase (NOX4) in tauopathy

10 Dec 2021

Abstract excerpt

Aggregates of the microtubule-associated protein tau are a common marker of neurodegenerative diseases collectively termed as tauopathies, such as Alzheimer's disease (AD) and frontotemporal dementia. Therapeutic strategies based on tau have failed in late stage clinical trials, suggesting that tauopathy may be the consequence of upstream causal mechanisms. As increasing levels of reactive oxygen species (ROS)...

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PMID: 34922273
DOI: 10.1016/j.redox.2021.102210

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