Article

Neuronal NADPH oxidase 2 in Parkinson’s disease pathogenesis

2021-05-15

Abstract excerpt

Mitochondrial dysfunction and oxidative stress are strongly implicated in the pathogenesis of Parkinson’s disease (PD) and there is evidence that mitochondrially-generated superoxide can activate NADPH oxidase 2 (NOX2), which is a major enzymatic generator of superoxide. Although NOX2 has been examined in the context of PD, previous studies have focused on microglial function; the role of neuronal NOX2 in PD patho...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 27fb815d-2ab2-5cc3-9859-1d7012b7019c
DOI: 10.1101/2021.05.13.443999

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Neuronal NADPH oxidase 2 in Parkinson’s disease pathogenesisDOI 10.1101/2021.05.13.443999Read

The Role of the NADPH Oxidase NOX2 in Prion PathogenesisSemantic proximity Read

NOX2-Derived Hydrogen Peroxide Impedes the AMPK/Akt-mTOR Signaling Pathway in Parkinson's Disease in Vitro ModelsSemantic proximity Read

Neuronal NOX4 knockdown alleviates pathological tau-related alterations in a humanized mouse model of tauopathySemantic proximity Read

Implication of type 4 NADPH oxidase (NOX4) in tauopathySemantic proximity Read

Molecular Roles of NADPH Oxidase-Mediated Oxidative Stress in Alzheimer’s Disease: Isoform-Specific ContributionsSemantic proximity Read

P2X7 receptor is critical in α-synuclein--mediated microglial NADPH oxidase activation.Semantic proximity Read

NOX2 Inhibition Enables Retention of the Circadian Clock in BV2 Microglia and Primary MacrophagesSemantic proximity Read

Role of the Transcription Factor Nrf2 in Parkinson’s Disease: New InsightsSemantic proximity Read

A distinct signalling circuit upregulates cytotoxic ROS production in a cellular model of Parkinson’s disease: key roles for TRPM2, Zn <sup>2+</sup> and complex IIISemantic proximity Read

Leucine-rich repeat kinase-2 (LRRK2) modulates microglial phenotype and dopaminergic neurodegeneration.Semantic proximity Read

A potential role for NADPH oxidase (NOX1/2) in mutant huntingtin-induced anomalous neurite outgrowth.Semantic proximity Read

Pharmacological Blocker of NF-κb and Mitochondrial Ros Restrict NLRP3 Inflammasome Activation and Rescue Dopaminergic Neurons in Vitro and in Vivo Parkinson’s DiseaseSemantic proximity Read