Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

miR-204-3p/Nox4 Mediates Memory Deficits in a Mouse Model of Alzheimer’s Disease

6 Sept 2020

Abstract excerpt

Alzheimer's disease (AD) is the most common neurodegenerative disorder leading to dementia in the elderly, and the mechanisms of AD are not fully defined. MicroRNAs (miRNAs) have been shown to contribute to memory deficits in AD. In this study, we identified that miR-204-3p was downregulated in the hippocampus and plasma of 6-month-old APPswe/PS1dE9 (APP/PS1) mice. miR-204-3p overexpression attenuated memory and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to MicroRNA in disease regulation
Share to Neuroinflammation and Neurodegeneration Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32950103
DOI: 10.1016/j.ymthe.2020.09.006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

miR-204-3p/Nox4 Mediates Memory Deficits in a Mouse Model of Alzheimer’s DiseasePMID 32950103Read ↗

Molecular Roles of NADPH Oxidase-Mediated Oxidative Stress in Alzheimer’s Disease: Isoform-Specific ContributionsSemantic proximity Read ↗

MicroRNA-574 is involved in cognitive impairment in 5-month-old APP/PS1 mice through regulation of neuritin.Semantic proximity Read ↗

Neuronal NOX4 knockdown alleviates pathological tau-related alterations in a humanized mouse model of tauopathySemantic proximity Read ↗

Molecular Insight into the Therapeutic Promise of Targeting APOE4 for Alzheimer's Disease.Semantic proximity Read ↗

MiR-214-3p attenuates cognition defects via the inhibition of autophagy in SAMP8 mouse model of sporadic Alzheimer's diseaseSemantic proximity Read ↗

Targeting MicroRNA-485-3p Blocks Alzheimer’s Disease ProgressionSemantic proximity Read ↗

Ginsenoside Rg1 alleviates Aβ deposition and neuronal damage by inhibiting NLRP1 inflammasome activation in APP/PS1 miceSemantic proximity Read ↗

Genome-Wide Analysis of miRNA Signature in the APPswe/PS1ΔE9 Mouse Model of Alzheimer's DiseaseSemantic proximity Read ↗

Spatiotemporal Dysregulation of Neuron–Glia Related Genes and Pro-/Anti-Inflammatory miRNAs in the 5xFAD Mouse Model of Alzheimer’s DiseaseSemantic proximity Read ↗

Neuronal deficiency of p38α‐MAPK ameliorates symptoms and pathology of APP or Tau‐transgenic Alzheimer’s mouse modelsSemantic proximity Read ↗

Amyloid β Protein Aggravates Neuronal Senescence and Cognitive Deficits in 5XFAD Mouse Model of Alzheimer's DiseaseSemantic proximity Read ↗

Implication of type 4 NADPH oxidase (NOX4) in tauopathySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.