Article

Isoform-selective NADPH oxidase inhibitor panel for pharmacological target validation

2018-08-01

Abstract excerpt

Unphysiological reactive oxygen species (ROS) formation is considered an important pathomechanism for several disease phenotypes with high unmet medical need. Therapeutically, antioxidants have failed multiple times. Instead, focusing on only disease-relevant, enzymatic sources of ROS appears to be a more promising and highly validated approach. Here the family of five NADPH oxidases (NOX) stands out as drug targe...

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Literature Corpus work: eec50ed8-b7b5-56ae-97bf-9b30cbb5a0a5
DOI: 10.1101/382226

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