Article
Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration.
PLoS biology - 21 Sept 2010
Kleinschnitz Christoph, Grund Henrike, Wingler Kirstin, Armitage Melanie E, Jones Emma, Mittal Manish, Barit David, Schwarz Tobias, Geis Christian, Kraft Peter, Barthel Konstanze, Schuhmann Michael K, Herrmann Alexander M, Meuth Sven G, Stoll Guido, Meurer Sabine, Schrewe Anja, Becker Lore, Gailus-Durner Valérie, Fuchs Helmut, Klopstock Thomas, de Angelis Martin Hrabé, Jandeleit-Dahm Karin, Shah Ajay M, Weissmann Norbert, Schmidt Harald H H W
Abstract excerpt
Ischemic stroke is the second leading cause of death worldwide. Only one moderately effective therapy exists, albeit with contraindications that exclude 90% of the patients. This medical need contrasts with a high failure rate of more than 1,000 pre-clinical drug candidates for stroke therapies. Thus, there is a need for translatable mechanisms of neuroprotection and more rigid thresholds of relevance in...
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