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Article

A potential role for NADPH oxidase (NOX1/2) in mutant huntingtin-induced anomalous neurite outgrowth.

Molecular and cellular neurosciences - 1 Sept 2025

Villegas Luisana Duque, Mathiesen Alberte Vad, Rasmussen Izabela, von Broich Maria, Qvist Filippa Liliendahl, Skotte Niels, Bardile Costanza Ferrari, Budtz-Jørgensen Esben, Freude Kristine, Schmid Benjamin, Pouladi Mahmoud A, Nørremølle Anne, Vilhardt Frederik

Abstract excerpt

Neurite growth is regulated by NADPH Oxidase (NOX1 and 2) and in this study, we investigate whether neuritic abnormalities observed in stem cell models of Huntington's disease relates to altered NOX function during NGF-driven differentiation of PC12 neuronal cells. NOX1 and 2 were contained in separate vesicular compartments, and by overexpression inhibited or promoted neurite extension, respectively. Expression...

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Identifiers

PMID: 40412581
DOI: 10.1016/j.mcn.2025.104012

Genes

NOX1
NGF
TSG101

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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