Axin-mediated regulation of lifespan and muscle health in <i>C. elegans</i> involves AMPK-FOXO signaling

Abstract excerpt

<h4>SUMMARY</h4> Aging is a significant risk factor for several diseases. Studies have uncovered multiple signaling pathways that modulate the process of aging including the Insulin/IGF-1 signaling (IIS). In C. elegans the key regulator of IIS is DAF-16/FOXO whose activity is regulated by phosphorylation. A major kinase involved in DAF-16-mediated lifespan extension is the AMPK catalytic subunit homolog, AAK-2....

Topics

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• Forkhead Transcription Factors
• FOXO transcription factor regulation
• Genetics, Aging, and Longevity in Model Organisms
• Germ Cells
• Insulin-Like Growth Factor I
• Longevity
• Proto-Oncogene Proteins c-akt
• Receptor, Insulin

Identifiers and source

Literature Corpus work

b88dc229-06d6-5a97-87cc-2047691f3a02

DOI

10.1101/2020.04.22.055962