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Article

A new DAF-16 isoform regulates longevity.

Nature - 22 Jul 2010

Kwon Eun-Soo, Narasimhan Sri Devi, Yen Kelvin, Tissenbaum Heidi A

Abstract excerpt

The insulin/IGF-1 signalling (IIS) pathway has diverse roles from metabolism to longevity. In Caenorhabditis elegans, the single forkhead box O (FOXO) homologue, DAF-16, functions as the major target of the IIS pathway. One of two isoforms, DAF-16a, is known to regulate longevity, stress response and dauer diapause. However, it remains unclear how DAF-16 achieves its specificity in regulating these various...

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Identifiers

PMID: 20613724
DOI: 10.1038/nature09184
PMCID: PMC3109862

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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