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Article

Longevity Genes Revealed by Integrative Analysis of Isoform-Specific daf-16/FoxO Mutants of Caenorhabditis elegans.

Genetics - 1 Oct 2015

Chen Albert Tzong-Yang, Guo Chunfang, Itani Omar A, Budaitis Breane G, Williams Travis W, Hopkins Christopher E, McEachin Richard C, Pande Manjusha, Grant Ana R, Yoshina Sawako, Mitani Shohei, Hu Patrick J

Abstract excerpt

FoxO transcription factors promote longevity across taxa. How they do so is poorly understood. In the nematode Caenorhabditis elegans, the A- and F-isoforms of the FoxO transcription factor DAF-16 extend life span in the context of reduced DAF-2 insulin-like growth factor receptor (IGFR) signaling. To elucidate the mechanistic basis for DAF-16/FoxO-dependent life span extension, we performed an integrative...

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Identifiers

PMID: 26219299
DOI: 10.1534/genetics.115.177998
PMCID: PMC4596673

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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