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The PP2A/4/6 subfamily of phosphoprotein phosphatases regulates DAF-16 during aging and confers resistance to environmental stress in postreproductive adult <i>C. elegans</i>

2020-02-18

Abstract excerpt

Insulin and insulin-like growth factors are longevity determinants that negatively regulate Forkhead box class O (FoxO) transcription factors. In C. elegans mutations that constitutively activate DAF-16, the ortholog of mammalian FoxO3a, extend lifespan by two-fold. While environmental insults induce DAF-16 activity in younger animals, it also becomes activated in an age-dependent manner in the absence of stress,...

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Literature Corpus work
e5a2d4ff-938d-551f-bb9d-f945b5e41ad8
DOI
10.1101/2020.02.18.953687
Open publication

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The PP2A/4/6 subfamily of phosphoprotein phosphatases regulates DAF-16 during aging and confers resistance to environmental stress in postreproductive adult <i>C. elegans</i>DOI 10.1101/2020.02.18.953687
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