Article
Caenorhabditis elegans DAF-16/FOXO transcription factor and its mammalian homologs associate with age-related disease
11 Sept 2015
Abstract excerpt
The insulin/IGF-1 signaling pathway is evolutionarily conserved and its function is mediated largely by FOXO transcription factors. Reduced insulin/IGF-1 signaling leads to translocation of FOXO proteins from the cytoplasm to the nucleus where they activate a set of genes that mediate oxidative stress, heat shock, and xenobiotic responses, innate immunity, metabolism, and autophagy. Disruptions in the...