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Axin-Mediated Regulation of Lifespan and Muscle Health in C. elegans Requires AMPK-FOXO Signaling

23 Nov 2020

Abstract excerpt

Aging is a significant risk factor for several diseases. Studies have uncovered multiple signaling pathways that modulate aging, including insulin/insulin-like growth factor-1 signaling (IIS). In Caenorhabditis elegans , the key regulator of IIS is DAF-16/FOXO. One of the kinases that affects DAF-16 function is the AMPK catalytic subunit homolog AAK-2. In this study, we report that PRY-1/Axin plays an essential...

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PMID: 33319173
DOI: 10.1016/j.isci.2020.101843

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Axin-Mediated Regulation of Lifespan and Muscle Health in C. elegans Requires AMPK-FOXO SignalingPMID 33319173Read ↗

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