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The Nuclear RNAi Pathway Regulates DAF-16/FOXO to Control <i>C. elegans</i> Longevity and <i>Dauer</i> Entry

2022-10-21

Abstract excerpt

<h4>ABSTRACT</h4> Caenorhabditis elegans with impaired insulin/IGF-1 receptor signalling (IIS) or with germline ablation live longer and this phenomenon is entirely dependent on the transcription factor DAF-16 - the C. elegans homolog of the class O of the forkhead box transcription factors (FoxO). In a candidate RNAi screen designed to search for new modifiers of DAF-16 function among genes involved in histone...

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Literature Corpus work: fff1b593-111e-546c-89b1-1005bc0378a2
DOI: 10.1101/2022.10.21.513151

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