Article

Three Muscle-Specific DAF-16/FOXO Transcriptional Targets Activated by Reduced Insulin/IGF-1 Signaling

2022-12-11

Abstract excerpt

C. elegans insulin/insulin-like growth factor 1 signaling, IIS, affects diverse physiological processes through the DAF-16/FOXO transcription factor. Despite its ubiquitous presence in somatic cells, DAF-16’s effects exhibit prevalent tissue specificity as well as tissue crosstalk. This implies that tissue-specific DAF-16 transcriptional programs contribute to functional diversity of IIS. To further investigate th...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 33930b1f-e37a-5cf6-9f49-f39ce3ec8972
DOI: 10.1101/2022.12.09.519372

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Three Muscle-Specific DAF-16/FOXO Transcriptional Targets Activated by Reduced Insulin/IGF-1 SignalingDOI 10.1101/2022.12.09.519372Read

Genome-wide endogenous DAF-16/FOXO recruitment dynamics during lowered insulin signalling in C. elegans.Semantic proximity Read

Transcriptome Analysis of Insulin Signaling-Associated Transcription Factors in C. elegans Reveal Their Genome-Wide Target Genes Specificity and Complexity.Semantic proximity Read

DAF-16: FOXO in the Context of C. elegans.Semantic proximity Read

Transcriptome analysis of adult Caenorhabditis elegans cells reveals tissue-specific gene and isoform expression.Semantic proximity Read

Axin-mediated regulation of lifespan and muscle health in <i>C. elegans</i> involves AMPK-FOXO signalingSemantic proximity Read

The C. elegans adult neuronal IIS/FOXO transcriptome reveals adult phenotype regulators.Semantic proximity Read

Transcriptome Analysis of Adult <i>C. elegans</i> Cells Reveals Tissue-specific Gene and Isoform ExpressionSemantic proximity Read

Direct and indirect gene regulation by a life-extending FOXO protein in C. elegans: roles for GATA factors and lipid gene regulators.Semantic proximity Read

DAF-16 target genes that control C. elegans life-span and metabolism.Semantic proximity Read

Endogenous DAF-16 Spatiotemporal Activity Quantitatively Predicts Lifespan Extension Induced by Dietary RestrictionSemantic proximity Read

DamID in C. elegans reveals longevity‐associated targets of DAF‐16/FoxOSemantic proximity Read

Axin-Mediated Regulation of Lifespan and Muscle Health in C. elegans Requires AMPK-FOXO SignalingSemantic proximity Read