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Article

DAF-16 target genes that control C. elegans life-span and metabolism.

Science (New York, N.Y.) - 25 Apr 2003

Lee Siu Sylvia, Kennedy Scott, Tolonen Andrew C, Ruvkun Gary

Abstract excerpt

Signaling from the DAF-2/insulin receptor to the DAF-16/FOXO transcription factor controls longevity, metabolism, and development in disparate phyla. To identify genes that mediate the conserved biological outputs of daf-2/insulin-like signaling, we used comparative genomics to identify 17 orthologous genes from Caenorhabditis and Drosophila, each of which bears a DAF-16 binding site in the promoter region....

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PMID: 12690206
DOI: 10.1126/science.1083614

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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