Article
Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling.
Nature genetics - 1 Jun 2001
Lin K, Hsin H, Libina N, Kenyon C
Abstract excerpt
The lifespan of Caenorhabditis elegans is regulated by the insulin/insulin-like growth factor (IGF)-1 receptor homolog DAF-2, which signals through a conserved phosphatidylinositol 3-kinase (PI 3-kinase)/Akt pathway. Mutants in this pathway remain youthful and active much longer than normal animals and can live more than twice as long. This lifespan extension requires DAF-16, a forkhead/winged-helix transcription...
Topics
- Animals
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Cell Nucleus
- Forkhead Transcription Factors
- Gene Expression Regulation
- Germ Cells
- Helminth Proteins
- Insulin
- Insulin-Like Growth Factor I
- Longevity
- Mutation
- Neurons, Afferent
- Phosphorylation