Article
The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans.
Nature - 30 Oct 1997
Ogg S, Paradis S, Gottlieb S, Patterson G I, Lee L, Tissenbaum H A, Ruvkun G
Abstract excerpt
In mammals, insulin signalling regulates glucose transport together with the expression and activity of various metabolic enzymes. In the nematode Caenorhabditis elegans, a related pathway regulates metabolism, development and longevity. Wild-type animals enter the developmentally arrested dauer...
Topics
- Alternative Splicing
- Amino Acid Sequence
- Animals
- Blood Proteins
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Cell Cycle Proteins
- DNA-Binding Proteins
- Forkhead Box Protein O1
- Forkhead Transcription Factors
- Helminth Proteins
- Humans
- Insulin
- Longevity
- Molecular Sequence Data
- Mutation
- Phosphatidylinositol 3-Kinases
- Receptor, Insulin