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Article

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans.

Nature - 30 Oct 1997

Ogg S, Paradis S, Gottlieb S, Patterson G I, Lee L, Tissenbaum H A, Ruvkun G

Abstract excerpt

In mammals, insulin signalling regulates glucose transport together with the expression and activity of various metabolic enzymes. In the nematode Caenorhabditis elegans, a related pathway regulates metabolism, development and longevity. Wild-type animals enter the developmentally arrested dauer stage in response to high levels of a secreted pheromone, accumulating large amounts of fat in their intestines and...

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PMID: 9353126
DOI: 10.1038/40194

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans.PMID 9353126Read ↗

DAF-16 target genes that control C. elegans life-span and metabolism.Semantic proximity Read ↗

daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans.Semantic proximity Read ↗

DAF-16-dependent and independent expression targets of DAF-2 insulin receptor-like pathway in Caenorhabditis elegans include FKBPs.Semantic proximity Read ↗

Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling.Semantic proximity Read ↗

PDP-1 links the TGF-β and IIS pathways to regulate longevity, development, and metabolism.Semantic proximity Read ↗

The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway.Semantic proximity Read ↗

An insulin-like signaling pathway affects both longevity and reproduction in Caenorhabditis elegans.Semantic proximity Read ↗

DAF-16: FOXO in the Context of C. elegans.Semantic proximity Read ↗

DAF-16/FoxO in Caenorhabditis elegans and Its Role in Metabolic Remodeling.Semantic proximity Read ↗

Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF-16.Semantic proximity Read ↗

Axin-mediated regulation of lifespan and muscle health in <i>C. elegans</i> involves AMPK-FOXO signalingSemantic proximity Read ↗

A new DAF-16 isoform regulates longevity.Semantic proximity Read ↗

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